Interesting thoughts from Scoble on screen resolution. I remember the early 1990s when 640x480 was the top acceptable to many business users -- I just couldn't get them to go to 800x600. Now with 17"+ monitors (rather than 14") 1024x768 is normal. But I still have to reset the flat panels to 1280x1024 when I return to one client (native resolution -- otherwise horrible artifacts).
The problem is operating system design. Even "large fonts" mode tends to be erratic, making some things bigger while most things stay the same (how about the condition where the same icons get separated by 2-3x the space for wasting screen space). Geeks love more data -- most low-end users only keep one application on the screen at a time. Show them better quality and they'll buy. Show them their one application just smaller (or even stuffed with more information) they'll refuse the alleged "upgrade". Bigger screen, yes.
To fix this, it has to be thought about from the ground up in the operating system. 1600x1200 should look exactly the same as 800x600 -- just in High Definition. Once that's the case, high resolution monitors will fly off the shelves. I'm sure we can find some legacy mode for microtext aficionados like Scoble and myself.